Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats.

ABSTRACT: Stroke is a disease of aging. In stroke patients, the enriched group that received stimulating physical, eating, socializing, and group activities resulted in higher activity levels including spending more time on upper limb, communal socializing, listening and iPad activities. While environmental enrichment has been shown to improve the behavioral outcome of stroke in young animals, the effect of an enriched environment on behavioral recuperation and histological markers of cellular proliferation, neuroinflammation, and neurogenesis in old subjects is not known. We used behavioral testing and immunohistochemistry to assess the effect of environment on post-stroke recovery of young and aged rats kept either in isolation or stimulating social, motor, and sensory environment (( +)Env). We pr

SUBMITTER: Gresita A 

PROVIDER: S-EPMC8811116 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature