Implementation of an Outpatient HD-MTX Initiative.

ABSTRACT:

Introduction

Methotrexate (MTX) a folate antagonist is often given in high doses (≥500 mg/m²) to treat a variety of disease processes. While inpatient administration has been the norm, outpatient administration, has been shown to be safe, effective, and patient centered. Here in we describe development of an outpatient HDMTX protocol and our initial experience.

Methods

All patients were to receive their first cycle of HDMTX in the hospital to ensure they tolerate it well and also to use this time to assist in training for home administration. The outpatient protocol involved continuous IV sodium bicarbonate, along with oral leucovorin and acetazolamide. Patients were required to visit the infusion center daily for labs and methotrexate levels. Clear criteria for a

SUBMITTER: Sokol K 

PROVIDER: S-EPMC8811119 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature