The Relative Contribution of Plasma Homocysteine Levels vs. Traditional Risk Factors to the First Stroke: A Nested Case-Control Study in Rural China.

ABSTRACT:

Background

Approximately 75% of Chinese hypertensive patients have elevated homocysteine (Hcy). Its implication in risk assessment and prevention of the first stroke remains an important clinical and public health question.

Methods

This study was based on a community cohort recruited from 2016 to 2018 in the rural China. To maximize cost efficiency, we used a nested case-control design, including 3,533 first stroke cases and 3,533 controls matched for age ±1 years, sex, and village. Individual associations of tHcy and traditional risk factors with the first stroke were examined, and their population-attributable risks (PARs) were estimated.

Results

There was a significant dose-response association between first stroke and total Hcy (tHcy) levels, with adjusted odds ra

SUBMITTER: Zhou F 

PROVIDER: S-EPMC8811122 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature