Gene Structure Analysis of Chemokines and Their Receptors in Allotetraploid Frog, Xenopus laevis.

ABSTRACT: Chemokines, relatively small secreted proteins, are involved in cell migration and function in various biological events, including immunity, morphogenesis, and disease. Due to their nature, chemokines tend to be a target of hijacking of immunity by virus and therefore show an exceptionally high mutation rate. Xenopus laevis is considered an excellent model to investigate the effect of whole-genome duplication for gene family evolution. Because its allotetraploidization occurred around 17-18 million years ago, ancestral subgenomes L and S were well conserved. Based on the gene model of human and diploid frog Xenopus tropicalis, we identified 52 chemokine genes and 26 chemokine receptors in X. laevis. The retention rate of the gene in the X. laevis L and S subgen

SUBMITTER: Fukui A 

PROVIDER: S-EPMC8811506 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature