An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs.

ABSTRACT:

Backgrounds & aims

Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening.

Methods

We combined new and existing genotype data for 10,516 cases and 20,772 controls from 5 European and 2 East Asian cohorts.

Results

We identified 56 genome-

SUBMITTER: Cordell HJ 

PROVIDER: S-EPMC8811537 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature