A Self-Degradable Conjugated Polymer for Photodynamic Therapy with Reliable Postoperative Safety.

ABSTRACT: As a noninvasive therapeutic technique, photodynamic therapy (PDT) has attracted numerous research interests for cancer therapy. Nevertheless, the residual photosensitizers (PSs) still produce reactive oxygen species (ROS) and damage normal cells under sunlight after PDT, which limits their practical application in clinic. Herein, the authors propose a self-degradable type-I PS based on conjugated polymer, which is composed of aggregation-induced emission (AIE) and imidazole units. Due to the effective conjugated skeleton and unique AIE properties, thus-obtained polymers can effectively generate superoxide radical (O₂ ^-• ) through the type-I process under light irradiation, which is ideal for hypoxic tumors treatment. Intriguingly, under light irradiation, O₂

SUBMITTER: Huang H 

PROVIDER: S-EPMC8811814 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature