Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System.

ABSTRACT: The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are associated with superficial mucosal damage and intermittent wounding that leads to epithelial barrier defects and increased permeability. The standard therapeutic interventions for colitis have focused mainly on maintaining the remission levels of the disease. Nonetheless, such treatment strategies (using anti-inflammatory, immunomodulatory agents) do not address colitis' root cause, especially the mucosal damage and dysregulated intestinal barrier functions. Restoration of barrier functionality by mucosal healing or physical barrier protecting strategies shall be considered as an initial event in the disease suppression and progression. Herein, a biphasic hyaluronan (HA) enema suspension, naïve-HA

SUBMITTER: Kotla NG 

PROVIDER: S-EPMC8811821 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature