Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.

ABSTRACT: RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, N⁶-methyladenine (m⁶A) is the most abundant RNA modification. Methyltransferase-like 14 (METTL14) is the central component of the m⁶A methylated transferase complex, which is involved in the dynamic reversible process of m⁶A modification. METTL14 acts as both an oncogene and tumor suppressor gene to regulate the occurrence and development of various cancers. The abnormal m⁶A level induced by METTL14 is related to tumorigenesis, proliferation, metastasis, and invasion. To date, the molecular mechanism of METTL14 in various malignant tumors has not been fully studied. In this paper, we

SUBMITTER: Guan Q 

PROVIDER: S-EPMC8812173 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature