RNA-seq of nine canine prostate cancer cell lines reveals diverse therapeutic target signatures.

ABSTRACT:

Background

Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) are typically characterized by metastasis and chemoresistance. Cell lines are important model systems for developing new therapeutic strategies. However, as they adapt to culturing conditions and undergo clonal selection, they can diverge from the tissue from which they were originally derived. Therefore, a comprehensive characterization of cell lines and their original tissues is paramount.

Methods

This study compared the transcriptomes of nine canine cell lines derived from PAC, PAC metastasis and TCC to their respective original primary tumor or metastasis tissues. Special interests were laid on cell culture-related differences, epithelial to mesenchymal transition (EMT), the prostate an

SUBMITTER: Packeiser EM 

PROVIDER: S-EPMC8812184 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature