An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.

ABSTRACT:

Background

The human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant mortality before the introduction of a vaccine in the 1980s. Although the occurrence of serotype b (Hib), the most virulent type of H. influenzae, has since decreased, reports of infections with other serotypes and non-typeable strains are on the rise. While non-typeable strains have been studied in-depth, very little is known of the pathogen's evolutionary history, and no genomes dating prior to 1940 were available.

Results

We describe a Hib genome isolated from a 6-year-old Anglo-Saxon plague victim, from approximately 540 to 550 CE, Edix Hill, England, showing signs of invasive infection on its skeleton. We find that the genome

SUBMITTER: Guellil M 

PROVIDER: S-EPMC8812261 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature