Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment.

ABSTRACT:

Background

Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10-20% of stage 4 patients, came to the fore of melanoma research, as it recently evolved as decisive indicator of treatment resistance to immune checkpoint inhibition.

Methods

Hepatic metastases were induced by intrasplenic injection of five different murine melanoma cell lines. The efficiencies of hepatic colonization, morphologic patterns, gene expression profiles and degree of vascularization were analyzed and Sorafenib was applied as anti-angiogenic treatment.

Results

WT31 melanoma showed the highest efficiency of hepatic colonization, while intermediate efficiencies were observed for B16F10 and RET, and low efficiencies

SUBMITTER: Wohlfeil SA 

PROVIDER: S-EPMC8812268 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature