Identification of key genes and biological pathways in Chinese lung cancer population using bioinformatics analysis.

ABSTRACT:

Background

Identification of accurate prognostic biomarkers is still particularly urgent for improving the poor survival of lung cancer patients. In this study, we aimed to identity the potential biomarkers in Chinese lung cancer population via bioinformatics analysis.

Methods

In this study, the differentially expressed genes (DEGs) in lung cancer were identified using six datasets from Gene Expression Omnibus (GEO) database. Subsequently, enrichment analysis was conducted to evaluate the underlying molecular mechanisms involved in progression of lung cancer. Protein-protein interaction (PPI) and CytoHubba analysis were performed to determine the hub genes. The GEPIA, Human Protein Atlas (HPA), Kaplan-Meier plotter, and TIMER databases were used to explore the hub genes. The

SUBMITTER: Liu P 

PROVIDER: S-EPMC8812315 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature