Constructing a Multiple Sclerosis Diagnosis Model Based on Microarray.

ABSTRACT:

Introduction

Multiple sclerosis is an immune-mediated demyelinating disorder of the central nervous system. Because of the complexity of etiology, pathology, clinical manifestations, and the diversity of classification, the diagnosis of MS is very difficult. We found that McDonald Criteria is very strict and relies heavily on the evidence for DIS and DIT. Therefore, we hope to find a new method to supplement the evidence and improve the accuracy of MS diagnosis.

Results

We finally selected GSE61240, GSE18781, and GSE185047 based on the GPL570 platform to build a diagnosis model. We initially selected 54 MS susceptibility locus genes identified by IMSGC and WTCCC2 as predictors for the model. After Random Forests and other series of screening, the logistic regression model wa

SUBMITTER: Li H 

PROVIDER: S-EPMC8812326 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature