Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox.

ABSTRACT:

Background

The nuclear receptor Rev-erbα/β, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated in heart diseases, but it is unknown whether cardiac molecular clock dysfunction is associated with the progression of any naturally occurring human heart diseases. Obesity paradox refers to the seemingly protective role of obesity for heart failure, but the mechanism is unclear.

Methods

We generated mouse lines with cardiac-specific Rev-erbα/β knockout (KO), characterized cardiac phenotype, conducted multi-omics (RNA-sequencing, chromatin immunoprecipitation sequencing, proteomics, and metabolomics) analyses, and performed dietary and pharmacologic

SUBMITTER: Song S 

PROVIDER: S-EPMC8812427 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature