Cellular homologs of the double jelly-roll major capsid proteins clarify the origins of an ancient virus kingdom.

ABSTRACT: Viruses are a distinct type of replicators that encode structural proteins encasing virus genomes in virions. For some of the widespread virus capsid proteins and other major components of virions, likely ancestors encoded by cellular life forms are identifiable. In particular, one of the most common capsid proteins, with the single jelly-roll (SJR) fold, appears to have evolved from a particular family of cellular carbohydrate-binding proteins. However, the double jelly-roll major capsid protein (DJR-MCP), the hallmark of the enormously diverse viruses of the kingdom Bamfordvirae within the realm Varidnaviria, which includes bacterial and archaeal icosahedral viruses as well as eukaryotic giant viruses, has been perceived as a virus innovation that evolved by duplication and

SUBMITTER: Krupovic M 

PROVIDER: S-EPMC8812541 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature