LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis.

ABSTRACT: Single-cell RNA-sequencing (scRNA-seq) has become a powerful tool for biomedical research by providing a variety of valuable information with the advancement of computational tools. Lineage analysis based on scRNA-seq provides key insights into the fate of individual cells in various systems. However, such analysis is limited by several technical challenges. On top of the considerable computational expertise and resources, these analyses also require specific types of matching data such as exogenous barcode information or bulk assay for transposase-accessible chromatin with high throughput sequencing (ATAC-seq) data. To overcome these technical challenges, we developed a user-friendly computational algorithm called "LINEAGE" (label-free identification of endogenous informative single-cell

SUBMITTER: Lin L 

PROVIDER: S-EPMC8812554 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature