Chromosomal microarray analysis vs. karyotyping for fetal ventriculomegaly: a meta-analysis.

ABSTRACT:

Background

Chromosomal abnormalities are important causes of ventriculomegaly (VM). In mild and isolated cases of fetal VM, obstetricians rarely give clear indications for pregnancy termination. We aimed to calculate the incidence of chromosomal abnormalities and incremental yield of chromosomal microarray analysis (CMA) in VM, providing more information on genetic counseling and prognostic evaluation for fetuses with VM.

Methods

The Chinese language databases Wanfang Data, China National Knowledge Infrastructure, and China Biomedical Literature Database (from January 1, 1991 to April 29, 2020) and English language databases PubMed, Embase, and Cochrane Library (from January 1, 1945 to April 29, 2020) were systematically searched for articles on fetal VM. Diagnostic criteria

SUBMITTER: Sun Y 

PROVIDER: S-EPMC8812611 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature