Comparison of the deep immune profiling of B cell subsets between healthy adults and Sjogren's syndrome.

ABSTRACT:

Objectives

Detailed analysis targeting B cell subgroups was considered crucial in monitoring autoimmune diseases and treatment responses. Thus, precisely describing the phenotypes of B cell differentiation and their variation in primary Sjögren's syndrome (pSS) is particularly needed.

Methods

To characterize the proportions and absolute counts of B cell subsets, peripheral blood from 114 healthy adults of China (age range: 19-73 years) and 55 patients with pSS were performed by flow cytometry and CD19, CD20, CD24, CD27, CD38 and IgD were used as surface markers to identify B cell mature process. Age- and gender-stratified analyses were then carried out to improve the interpretation of B cell subsets.

Results

The assessments from healthy adults showed that the proporti

SUBMITTER: Feng R 

PROVIDER: S-EPMC8812739 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature