Effects of Unilateral Stimulation in Parkinson's Disease: A Randomized Double-Blind Crossover Trial.

ABSTRACT:

Introduction

Previous studies have shown that subthalamic nucleus (STN) and unilateral globus pallidus interna (GPi) are similarly effective in the deep brain stimulation (DBS) treatment of motor symptoms. However, the counterintuitively more common clinical application of STN DBS makes us hypothesize that STN is superior to GPi in the treatment of motor symptoms.

Methods

In this prospective, double-blind, randomized crossover study, idiopathic PD patients treated with combined unilateral STN and contralateral GPi DBS (STN in one brain hemisphere and GPi in the other) for 2 to 3 years were enrolled. The MDS UPDRS-III total score and subscale scores for axial and bilateral limb symptoms were assessed preoperatively and at 2- to 3-year follow-up in four randomized, double-blin

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC8812849 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature