The rates and measurement of adherence to acamprosate in randomised controlled clinical trials: A systematic review.

ABSTRACT:

Aim

The current research aims to systematically review the rates of adherence reported in randomised controlled clinical trials of acamprosate. It also sought to determine the reliability of the adherence monitoring and measurement methods used in these trials.

Methods

The protocol for this review was pre-registered (PROSPERO: CRD42021230011). A search of the literature was conducted using OVID MEDLINE, Embase and PsycINFO from database inception to January 2021. Randomised controlled trials with a minimum sample size of 10 per treatment arm that compared the efficacy of acamprosate with placebo or other active medication in adults with a diagnosis of alcohol dependence were included. Data on rates of adherence, methods of measurement and monitoring of adherence was extracte

SUBMITTER: Donoghue K 

PROVIDER: S-EPMC8812903 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature