Zinc protoporphyrin levels in COVID-19 are indicative of iron deficiency and potential predictor of disease severity.

ABSTRACT:

Background

Coronavirus disease (COVID-19) has a severe impact on all aspects of patient care. Among the numerous biomarkers of potential validity for diagnostic and clinical management of COVID-19 are biomarkers at the interface of iron metabolism and inflammation.

Methods

The follow-up study included 54 hospitalized patients with laboratory-confirmed COVID-19 with a moderate and severe/critical form of the disease. Iron deficiency specific biomarkers such as iron, ferritin, transferrin receptor, hepcidin, and zinc protoporphyrin (ZnPP) as well as relevant markers of inflammation were evaluated twice: in the first five days when the patient was admitted to the hospital and during five to 15 days; and their validity to diagnose iron deficiency was further assessed. The regres

SUBMITTER: Kilercik M 

PROVIDER: S-EPMC8812978 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature