The structural coverage of the human proteome before and after AlphaFold.

ABSTRACT: The protein structure field is experiencing a revolution. From the increased throughput of techniques to determine experimental structures, to developments such as cryo-EM that allow us to find the structures of large protein complexes or, more recently, the development of artificial intelligence tools, such as AlphaFold, that can predict with high accuracy the folding of proteins for which the availability of homology templates is limited. Here we quantify the effect of the recently released AlphaFold database of protein structural models in our knowledge on human proteins. Our results indicate that our current baseline for structural coverage of 48%, considering experimentally-derived or template-based homology models, elevates up to 76% when including AlphaFold predictions. At the same

SUBMITTER: Porta-Pardo E 

PROVIDER: S-EPMC8812986 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature