DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample.

ABSTRACT: Accumulating evidence suggests that individuals exposed to victimization at key developmental stages may have different epigenetic fingerprints compared to those exposed to no/minimal stressful events, however results are inconclusive. This study aimed to strengthen causal inference regarding the impact of adolescent victimization on the epigenome by controlling for genetic variation, age, gender, and shared environmental exposures. We conducted longitudinal epigenome-wide association analyses (EWAS) on DNA methylation (DNAm) profiles of 118 monozygotic (MZ) twin pairs from the Environmental Risk study with and without severe adolescent victimization generated using buccal DNA collected at ages 5, 10 and 18, and the Illumina EPIC array. Additionally, we performed cross-sectional EWAS on ag

SUBMITTER: Kandaswamy R 

PROVIDER: S-EPMC8813077 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature