Epigenome-wide association study and network analysis for IgA Nephropathy from CD19⁺ B-cell in Chinese Population.

ABSTRACT: IgA nephropathy (IgAN) is the most common primary glomerular disease in China and worldwide. The proliferation of B cells is known to be associated with both risk and prognosis of IgAN, but the epigenetic mechanism underlying this association is unknown. In this study we carried out the first Epigenome-wide Association Study (EWAS) by using the latest Infinium Methylation EPIC BeadChip on 184 B cell-specific samples (92 case/control pairs) for Chinese IgAN population. After rigorous data normalization and residual batch effect correction, linear mixed effect model was used to detect methylation CpG sites associated with IgAN adjusting for age, gender and smoking. False discovery rate (FDR) less than 10% was used to account for multiple testing. Weighted gene co-methylation networks

SUBMITTER: Lin Y 

PROVIDER: S-EPMC8813080 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature