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Marine and Anthropogenic Bromopyrroles Alter Cellular Ca²⁺ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca²⁺-ATPase.

ABSTRACT: Bromopyrroles (BrPyr) are synthesized naturally by marine sponge symbionts and produced anthropogenically as byproducts of wastewater treatment. BrPyr interact with ryanodine receptors (RYRs) and sarco/endoplasmic reticulum (SR/ER) Ca²⁺-ATPase (SERCA). Influences of BrPyr on the neuronal network activity remain uncharted. BrPyr analogues with differing spectra of RYR/SERCA activities were tested using RYR-null or RYR1-expressing HEK293 and murine cortical neuronal/glial cocultures (NGCs) loaded with Fluo-4 to elucidate their mechanisms altering Ca²⁺ dynamics. The NGC electrical spike activity (ESA) was measured from NGCs plated on multielectrode arrays. Nanomolar tetrabromopyrrole (TBP, 1) potentiated caffeine-triggered Ca²⁺ release independent of ex

SUBMITTER: Zheng J

PROVIDER: S-EPMC8813095 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Dataset Information

Marine and Anthropogenic Bromopyrroles Alter Cellular Ca²⁺ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca²⁺-ATPase.

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Dataset Information

Marine and Anthropogenic Bromopyrroles Alter Cellular Ca2+ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca2+-ATPase.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Marine and Anthropogenic Bromopyrroles Alter Cellular Ca²⁺ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca²⁺-ATPase.