Spatial and temporal evolution of lung granulomas in a cynomolgus macaque model of Mycobacterium tuberculosis infection.

ABSTRACT:

Background

Little is known about granuloma progression of Mycobacterium tuberculosis infection in humans. Using serial positron emission tomography and computed tomography (PET/CT) of an animal model that recapitulates human infection with M. tuberculosis, we are able to track lung granulomas.

Objective

We characterized the spatial and temporal pattern of granuloma formation during primary infection and reactivation.

Methods

Serial PET/CT was performed on cynomolgus macaques (n = 28) during primary and reactivation M. tuberculosis infection. Distances between granulomas during the first six weeks post infection ("primary" granulomas) were compared to new granulomas that developed afterwards ("secondary" granulomas) using nearest neighbor analysis

SUBMITTER: Gregg RW 

PROVIDER: S-EPMC8813170 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature