Screening Gene Expression-Related Alternative Splicing Event Signature for Colon Cancer Prognostic Prediction.

ABSTRACT: Colon cancer is a kind of common intestinal disease, and early diagnosis of colon cancer is crucial for patient's prognosis. RNA alternative splicing (AS) is an RNA modification that affects cancer occurrence. RNA AS detection is promising to improve the in-depth understanding of the pathological mechanisms in colon cancer. In this study, differential analysis was performed to determine colon cancer-related AS events and the corresponding parental genes. Subsequently, GO functional annotation analysis was carried out on the parental genes, which revealed that these AS events might affect cell adhesion and cell growth. Besides, protein-protein interaction (PPI) network was established with the parental genes, in which MCODE was utilized to identify major functional modules. Enrichment analy

SUBMITTER: Xu J 

PROVIDER: S-EPMC8813276 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature