Pathogenomic analyses of Shigella isolates inform factors limiting shigellosis prevention and control across LMICs.

ABSTRACT: Shigella spp. are the leading bacterial cause of severe childhood diarrhoea in low- and middle-income countries (LMICs), are increasingly antimicrobial resistant and have no widely available licenced vaccine. We performed genomic analyses of 1,246 systematically collected shigellae sampled from seven countries in sub-Saharan Africa and South Asia as part of the Global Enteric Multicenter Study (GEMS) between 2007 and 2011, to inform control and identify factors that could limit the effectiveness of current approaches. Through contemporaneous comparison among major subgroups, we found that S. sonnei contributes ≥6-fold more disease than other Shigella species relative to its genomic diversity, and highlight existing diversity and adaptative capacity among S. flexneri that may generate vacci

SUBMITTER: Bengtsson RJ 

PROVIDER: S-EPMC8813619 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature