Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.

ABSTRACT:

Background

The macular central 1 mm diameter zone is crucial to patients' visual acuity, but the long-term natural history of central sparing in eyes with geographic atrophy (GA) is unknown.

Methods

We manually segmented GA in 210 eyes with GA involving central 1 mm diameter zone (mean follow-up=3.8 years) in the Age-Related Eye Disease Study. We measured the residual area in central 1 mm diameter zone and calculated central residual effective radius (CRER) as square root of (residual area/π). A linear mixed-effects model was used to model residual size over time. We added a horizontal translation factor to each data set to account for different durations of GA involving the central zone.

Results

The decline rate of central residual area was associated with baseline r

SUBMITTER: Shen LL 

PROVIDER: S-EPMC8813644 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature