Mechanical Properties in the Glioma Microenvironment: Emerging Insights and Theranostic Opportunities.

ABSTRACT: Gliomas represent the most common malignant primary brain tumors, and a high-grade subset of these tumors including glioblastoma are particularly refractory to current standard-of-care therapies including maximal surgical resection and chemoradiation. The prognosis of patients with these tumors continues to be poor with existing treatments and understanding treatment failure is required. The dynamic interplay between the tumor and its microenvironment has been increasingly recognized as a key mechanism by which cellular adaptation, tumor heterogeneity, and treatment resistance develops. Beyond ongoing lines of investigation into the peritumoral cellular milieu and microenvironmental architecture, recent studies have identified the growing role of mechanical properties of the microenvironme

SUBMITTER: Bhargav AG 

PROVIDER: S-EPMC8813748 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature