Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies.

ABSTRACT: The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates to disease risk. However, DNAm studies can be biased by cell type heterogeneity, so it is essential to control for this in order to reduce confounding and increase precision. Computational cell type deconvolution approaches have proven to be very useful for this purpose. For human placenta, however, an assessment of the performance of these estimation methods is still lacking. Here, we examine the performance of a newly available reference-based cell type estimation approach and compare it to an often-used reference-free cell type estimation approach, namely RefFreeEWAS, in placental

SUBMITTER: Dieckmann L 

PROVIDER: S-EPMC8813756 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature