Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.

ABSTRACT:

Background and objectives

Physiologically based pharmacokinetic (PBPK) modelling has evolved to accommodate different routes of drug administration and enables prediction of drug concentrations in tissues as well as plasma. The inhalation route of administration has proven successful in treating respiratory diseases but can also be used for rapid systemic delivery, holding great promise for treatment of diseases requiring systemic exposure. The objective of this work was to develop a PBPK model that predicts plasma and tissue concentrations following inhalation administration of the PI3Kδ inhibitor nemiralisib.

Methods

A PBPK model was built in GastroPlus^® that includes a complete mechanistic description of pulmonary absorption, systemic distribution and oral abso

SUBMITTER: Miller NA 

PROVIDER: S-EPMC8813803 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature