Microglial Activation and Neurological Outcomes in a Murine Model of Cardiac Arrest.

ABSTRACT:

Background

Neurological injury following successful resuscitation from sudden cardiac arrest (CA) is common. The pathophysiological basis of this injury remains poorly understood, and treatment options are limited. Microglial activation and neuroinflammation are established contributors to many neuropathologies, such as Alzheimer disease and traumatic brain injury, but their potential role in post-CA injury has only recently been recognized. Here, we hypothesize that microglial activation that occurs following brief asystolic CA is associated with neurological injury and represents a potential therapeutic target.

Methods

Adult C57BL/6 male and female mice were randomly assigned to 12-min, KCl-induced asystolic CA, under anesthesia and ventilation, followed by successful card

SUBMITTER: Ousta A 

PROVIDER: S-EPMC8813848 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature