Genetically targeting the BATF family transcription factors BATF and BATF3 in the mouse abrogates effector T cell activities and enables long-term heart allograft survival.

ABSTRACT: T cells must be activated and become effectors first before executing allograft rejection, a process that is regulated by diverse signals and transcription factors. In this study, we studied the basic leucine zipper ATF-like transcription factor (BATF) family members in regulating T cell activities in a heart transplant model and found that mice deficient for both BATF and BATF3 (Batf^-/- Batf3^-/- mice) spontaneously accept the heart allografts long-term without tolerizing therapies. Similarly, adoptive transfer of wild type T cells into Rag1^-/- hosts induced prompt rejection of heart and skin allografts, whereas the Batf^-/- Batf3^-/- T cells failed to do so. Analyses of graft-infiltrating cells showed that Batf^-/- Batf3^-

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8813885 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature