Midline Shift Greater than 3 mm Independently Predicts Outcome After Ischemic Stroke.

ABSTRACT:

Background

Cerebral edema is associated with worse outcome after acute stroke; however, the minimum clinically relevant threshold remains unknown. This study aimed to identify the minimal degree of midline shift (MLS) that predicts outcome in a cohort encompassing a broad range of patients with acute stroke.

Methods

Patient-level data from six acute stroke clinical trials were combined with endovascular thrombectomy registries from two academic referral centers, generating a combined cohort of 1977 patients. MLS was extracted from the original trial data or measured on computed tomography or magnetic resonance imaging that was obtained a median of 47.0 h (interquartile range 27.0-75.1 h) after stroke onset. Logistic regression was performed to identify predictors of poor out

SUBMITTER: McKeown ME 

PROVIDER: S-EPMC8813904 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature