IL-1β Impacts Vascular Integrity and Lymphatic Function in the Embryonic Omentum.

ABSTRACT:

Background

The chromatin-remodeling enzyme BRG1 (brahma-related gene 1) regulates gene expression in a variety of rapidly differentiating cells during embryonic development. However, the critical genes that BRG1 regulates during lymphatic vascular development are unknown.

Methods

We used genetic and imaging techniques to define the role of BRG1 in murine embryonic lymphatic development, although this approach inadvertently expanded our study to multiple interacting cell types.

Results

We found that omental macrophages fine-tune an unexpected developmental process by which erythrocytes escaping from naturally discontinuous omental blood vessels are collected by nearby lymphatic vessels. Our data indicate that circulating fibrin(ogen) leaking from gaps in omental blood

SUBMITTER: Menendez M 

PROVIDER: S-EPMC8813910 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature