Associations and recovery dynamics of the nasopharyngeal microbiota during influenza-like illness in the aging population.

ABSTRACT: Influenza-like illness (ILI), a disease caused by respiratory pathogens including influenza virus, is a major health concern in older adults. There is little information on changes and recovery dynamics of the nasopharyngeal (NP) microbiota of older adults associated with an ILI. Here, we compared the NP microbiota in older adults reporting (n = 240) or not (n = 157) ILI during the 2014-2015 influenza season at different times of the ILI event. A small but significant effect of the ILI was observed on the microbiota community composition and structure when compared to controls and samples collected at recovery. Corynebacterium was negatively associated with ILI and its abundance increased after recovery. Potential pathobionts such as Haemophilus, Porphyromonas and Gemella had higher abunda

SUBMITTER: Shetty SA 

PROVIDER: S-EPMC8813934 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature