The Mutational Landscape of Early-Onset Breast Cancer: A Next-Generation Sequencing Analysis.

ABSTRACT:

Background

Around 5%-7% of breast cancer cases are diagnosed in women younger than 40, making it the leading cause of female cancer in the 25- to 39-year-old age group. Unfortunately, young age at diagnosis is linked to a more aggressive tumor biology and a worse clinical outcome. The identification of the mutational landscape of breast cancer in this age group could optimize the management.

Methods

We performed NGS analysis in paraffin blocks and blood samples of 32 young patients with breast cancer [<40 years] and 90 older patients during the period 2019 through 2021. All patients were treated in a single institution at the Oncology Department of "Alexandra" Hospital, Medical School, University of Athens, Greece.

Results

Breast tumors were characterized more frequen

SUBMITTER: Andrikopoulou A 

PROVIDER: S-EPMC8813959 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature