Cardiovascular Phenotypes Profiling for L-Transposition of the Great Arteries and Prognosis Analysis.

ABSTRACT:

Objectives

Congenitally corrected transposition of the great arteries (ccTGA) is a rare and complex congenital heart disease with the characteristics of double discordance. Enormous co-existed anomalies are the culprit of prognosis evaluation and clinical decision. We aim at delineating a novel ccTGA clustering modality under human phenotype ontology (HPO) instruction and elucidating the relationship between phenotypes and prognosis in patients with ccTGA.

Methods

A retrospective review of 270 patients diagnosed with ccTGA in Fuwai hospital from 2009 to 2020 and cross-sectional follow-up were performed. HPO-instructed clustering method was administered in ccTGA risk stratification. Kaplan-Meier survival, Landmark analysis, and cox regression analysis were used to investigate

SUBMITTER: He Q 

PROVIDER: S-EPMC8814104 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature