Ceramide Composition in Exosomes for Characterization of Glioblastoma Stem-Like Cell Phenotypes.

ABSTRACT: Glioblastoma (GBM) is one of the most malignant central nervous system tumor types. Comparative analysis of GBM tissues has rendered four major molecular subtypes. From them, two molecular subtypes are mainly found in their glioblastoma cancer stem-like cells (GSCs) derived in vitro: proneural (PN) and mesenchymal (MES) with nodular (MES-N) and semi-nodular (MES-SN) disseminations, which exhibit different metabolic, growth, and malignancy properties. Many studies suggest that cancer cells communicate between them, and the surrounding microenvironment, via exosomes. Identifying molecular markers that allow the specific isolation of GSC-derived exosomes is key in the development of new therapies. However, the differential exosome composition produced by main GSCs remains unknow

SUBMITTER: Melero-Fernandez de Mera RM 

PROVIDER: S-EPMC8814423 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature