Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome.

ABSTRACT:

Background

Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms after viral clearance remains unclear.

Objective

To investigate whether gut microbiome composition is linked to post-acute COVID-19 syndrome (PACS), defined as at least one persistent symptom 4 weeks after clearance of the SARS-CoV-2 virus.

Methods

We conducted a prospective study of 106 patients with a spectrum of COVID-19 severity followed up from admission to 6 months and 68 non-COVID-19 controls. We analysed serial faecal microbiome of 258 samples using shotgun metagenomic sequencing, and correlated the results with persistent symptoms at 6 months.

Results

At 6 months, 76% of patients had PACS and the most common symptoms were fatigue, poor memory a

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8814432 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature