Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort.

ABSTRACT:

Background

The AtyPical Asthma in China (APAC) cohort is a multi-center prospective, observational cohort set-up to investigate the clinical, pathophysiological features, prognosis, and mechanisms of cough variant asthma (CVA).

Objectives

To present the characteristics of newly physician-diagnosed adults with CVA (n = 328) compared to mild-moderate classic asthma (CA, n = 206).

Methods and main results

CVA subjects showed a higher proportion of female (67.1 vs. 55.3%, P = 0.0084), abnormal laryngopharyngeal sensations (71 vs. 51%, p < 0.0001) than CA, but presented with near normal spirometry and higher methacholine PD20-FEV1 values [4.2 (1, 8.6) vs. 0.8 (0.4, 4.7), P < 0.0001]. Lower fractional exhaled nitric oxide (FENO) levels [38

SUBMITTER: Lai K 

PROVIDER: S-EPMC8814600 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature