The Median Effective Concentration (EC₅₀) of Epidural Ropivacaine With Different Doses of Oxycodone During Limb Surgery in Elderly Patients.

ABSTRACT:

Background

Oxycodone can be used both intravenously and epidurally in elderly patients because of its strong analgesic effect and more slight respiratory inhibition compared with other opioids at the same effect. In this study, we determined the median effective concentration (EC₅₀) of epidural ropivacaine required for great saphenous vein surgery in elderly patients in order to describe its pharmacodynamic interaction with oxycodone.

Methods

One hundred forty-one elderly patients scheduled for high ligation and stripping of the great saphenous vein surgery were allocated into three groups in a randomized, double-blinded manner as follows: Q2.5 group (2.5 mg oxycodone), Q5.0 group (5.0 mg oxycodone), and C group (normal saline). Anesthesia, was achieved with epidu

SUBMITTER: Xie K 

PROVIDER: S-EPMC8814631 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature