Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells.

ABSTRACT: Acute kidney injury is associated with mortality in COVID-19 patients. However, host cell changes underlying infection of renal cells with SARS-CoV-2 remain unknown and prevent understanding of the molecular mechanisms that may contribute to renal pathology. Here, we carried out quantitative translatome and whole-cell proteomics analyses of primary renal proximal and distal tubular epithelial cells derived from human donors infected with SARS-CoV-2 or MERS-CoV to disseminate virus and cell type-specific changes over time. Our findings revealed shared pathways modified upon infection with both viruses, as well as SARS-CoV-2-specific host cell modulation driving key changes in innate immune activation and cellular protein quality control. Notably, MERS-CoV infection-induced specific changes

SUBMITTER: Kohli A 

PROVIDER: S-EPMC8814637 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature