Episodic Memory Impairment Mediates the Loss of Awareness in Mild Cognitive Impairment.

ABSTRACT:

Introduction

Loss of awareness is a common symptom in Alzheimer's Disease (AD) and responsible for a significant loss of functional abilities. The mechanisms underlying loss of awareness in AD is unknown, although previous findings have implicated dysfunction of primary executive functioning (EF) or episodic memory (EM) to be the cause. Therefore, our main study objective was to explore the involvement of EF and EM dysfunction in amyloid-related loss of awareness across the clinical spectrum of AD.

Methods

A total of 895 participants (362 clinically normal [CN], 422 people with mild cognitive impairment [MCI] and 111 with dementia) from the Alzheimer's Disease Neuroimaging Initiative were used for the analyses. A sub-analysis was performed in 202 participants who progressed

SUBMITTER: Gagliardi G 

PROVIDER: S-EPMC8814670 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature