Effects of non-invasive brain stimulation in multiple sclerosis: systematic review and meta-analysis.

ABSTRACT:

Objective

The objective of this meta-analysis was to summarize evidence on the therapeutic effects of non-invasive brain stimulation (NIBS) on core symptoms of multiple sclerosis (MS). Specifically, findings from studies deploying transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) protocols were summarized in this review.

Methods

We systematically searched articles published in four databases, until 31 May 2021, which compared the effects of active tDCS or rTMS with sham intervention in MS patients. We used a random-effects model for this meta-analysis. Meta-regression and subgroup meta-analysis were used to examine the effects of stimulation dose and different stimulation protocols, respectively.

Results

Twenty-five

SUBMITTER: Kan RLD 

PROVIDER: S-EPMC8814979 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature