Peptide-Modified Nano-Bioactive Glass for Targeted Immobilization of Native VEGF.

ABSTRACT: A limiting factor in large bone defect regeneration is the slow and disorganized formation of a functional vascular network in the defect area, often resulting in delayed healing or implant failure. To overcome this, strategies that induce angiogenic processes should be combined with potent bone graft substitutes in new bone regeneration approaches. To this end, we describe a unique approach to immobilize the pro-angiogenic growth factor VEGF₁₆₅ in its native state on the surface of nanosized bioactive glass particles (nBGs) via a binding peptide (PR1P). We demonstrate that covalent coupling of the peptide to amine functional groups grafted on the nBG surface allows immobilization of VEGF with high efficiency and specificity. The amount of coupled peptide could be controlled by

SUBMITTER: Schumacher M 

PROVIDER: S-EPMC8815037 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature