Influence of Ion Source Geometry on the Repeatability of Topographically Guided LAESI-MSI.

ABSTRACT: Spatially resolving the relative distribution of analyte molecules in biological matter holds great promise in the life sciences. Mass spectrometry imaging (MSI) is a technique that can provide such spatial resolution but remains underused in fields such as chemical ecology, as traditional MSI sample preparation is often chemically or morphologically invasive. Laser ablation electrospray ionization (LAESI)-MSI is a variation of MSI particularly well-suited for situations where chemical sample preparation is too invasive but provides new challenges related to the repeatability of measurement outcomes. We assess the repeatability of LAESI-MSI by sampling a droplet of [ring-¹³C₆]l-phenylalanine with known concentration and expressing the resulting variability as a coeffi

SUBMITTER: Bartels B 

PROVIDER: S-EPMC8815068 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature