Moderate Intensity Exercise in Pre-manifest Huntington's Disease: Results of a 6 months Trial.

ABSTRACT:

Background

While it has been shown that aerobic exercise interventions are well tolerated in participants with the Huntington disease (HD) gene mutation, no study to date has tested whether an aerobic exercise intervention benefits brain structure and function in pre-manifest HD.

Objective

In this study we utilized magnetic resonance (MR) imaging techniques to assess the efficacy of moderate-to-vigorous exercise treatment relative to active stretching and toning control.

Methods

Forty pre-manifest participants with confirmed HD gene expansion were recruited into a two-arm intervention study that included a moderate-to-vigorous intensity home-based walking exercise intervention (N=34) and an active stretching and toning control intervention (N=6). Participants were ass

SUBMITTER: Aldine AS 

PROVIDER: S-EPMC8815110 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature