Similarities and differences between rat and mouse chondrocyte gene expression induced by IL-1β.

ABSTRACT:

Background

Osteoarthritis (OA) is the most prevalent degenerative joint disease. In vitro experiments are an intuitive method used to investigate its early pathogenesis. Chondrocyte inflammation models in rats and mice are often used as in vitro models of OA. However, similarities and differences between them in the early stages of inflammation have not been reported.

Objective

This paper seeks to compare the chondrocyte phenotype of rats and mice in the early inflammatory state and identify chondrocytes suitable for the study of early OA.

Methods

Under similar conditions, chondrocytes from rats and mice were stimulated using the same IL-1β concentration for a short period of time. The phenotypic changes of chondrocytes were observed under a microscope. The treated ch

SUBMITTER: Ding DF 

PROVIDER: S-EPMC8815127 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature